Demolitions are due to get underway later this month as the next phase of the £100 million South Shields 365 masterplan gathers pace.
Hoardings are being erected around the town centre to mark out the demolition site compound.
It is necessary to demolish some buildings to facilitate construction of the new Transport Interchange, which will start next Spring.
Demolitions will begin on Keppel Street, with the former Post Office and Royal Mail building, and the former Dawson and Sanderson travel agent.
Bowmer and Kirkland, who helped deliver The Word in Phase 1 of the masterplan, has been appointed demolition contractor
Councillor Iain Malcolm, Leader of South Tyneside Council, said: "A lot of hard work has been going on for quite some time behind the scenes, but from now members of the public will start to see activity happening around the town.
"Things are starting to move swiftly now, and in just a few months we'll be starting to build our superb new transport interchange.
"Regeneration is a gradual process, it doesn't happen overnight, but South Shields is undergoing a transformation.
"We are creating the right infrastructure to showcase our redeveloped town centre to residents and visitors."
The demolitions programme is likely to last around three months, during which time businesses will be open as usual.
The hoardings will show artist's impressions of how the new transport interchange will look, as well as vibrant new artwork reflecting the vision for South Shields and showcasing its fantastic visitor offer.
Planning permission was granted last year for the transport interchange, as well as outline planning permission for Phase three, new retail and leisure development.
The project received £9.4m from the Local Growth Deal through the North East Local Enterprise Partnership. The Local Growth Deal is supporting major capital investments to promote innovation, economic and skills infrastructure and sustainable transport across the North East LEP area.